How Sample Completeness Affects Gamma-Ray Burst Classification

Unsupervised pattern recognition algorithms support the existence of three gamma-ray burst classes; Class I (long, large fluence bursts of intermediate spectral hardness), Class II (short, small fluence, hard bursts), and Class III (soft bursts of intermediate durations and fluences). The algorithms surprisingly assign larger membership to Class III than to either of the other two classes. A known systematic bias has been previously used to explain the existence of Class III in terms of Class I; this bias allows the fluences and durations of some bursts to be underestimated (Hakkila et al., ApJ 538, 165, 2000). We show that this bias primarily affects only the longest bursts and cannot explain the bulk of the Class III properties. We resolve the question of Class III existence by demonstrating how samples obtained using standard trigger mechanisms fail to preserve the duration characteristics of small peak flux bursts. Sample incompleteness is thus primarily responsible for the existence of Class III. In order to avoid this incompleteness, we show how a new dual timescale peak flux can be defined in terms of peak flux and fluence. The dual timescale peak flux preserves the duration distribution of faint bursts and correlates better with spectral hardness (and presumably redshift) than either peak flux or fluence. The techniques presented here are generic and have applicability to the studies of other transient events. The results also indicate that pattern recognition algorithms are sensitive to sample completeness; this can influence the study of large astronomical databases such as those found in a Virtual Observatory.Comment: 29 pages, 6 figures, 3 tables, Accepted for publication in The Astrophysical Journa

Glutathione in calf trabecularmeshwork and its relation to aqueous humor outflow facility,”

Previous studies have shown that sulfhydryl reagents can alter the facility of aqueous humor outflow but little is known about the sulfhydryl constituents of the aqueous outflow system or the effect of oxidants upon outflow facility. In the present study the concentration of glutathione (GSH) was measured in excised calf trabecular meshwork (TM) and found to be 0.40 n mol/g wet wt (0.027 n mol/mg protein). Oxidized glutathione was not detectable in the tissue. TM was found to have significant hexose monophosphate shunt activity as determined by measurement of the oxidation of 14C-1 and 14C-6-labeled glucose in tissue homogenates. The concentration of GSH in TM of enucleated calf eyes could be totally depleted by infusion of medium containing both diamide, which is an oxidant of GSH, and l,3bis(2-chlorethyl)-l-nitrosourea (BCNU), which is an inhibitor of the enzyme glutathione reductase. The depletion of GSH was found to have no effect on the facility of aqueous outflow. Experiments were also done in which normal and TM GSH-depleted eyes were perfused with medium containing H202. Exposure to H202 produced no effect on outflow facility in the normal eyes but caused a 33% decrease in facility in eyes with the GSH-depleted TM. The results indicate that GSH may not participate directly in regulating aqueous humor outflow but is able to protect TM against H202-induced oxidative damage that would otherwise lead to a decrease in outflow facility. Invest Ophthalmol Vis Sci 24:1283-1287, 1983 Anterior chamber perfusion studies have shown that the presence of sulfhydryl (-SH) reagents can alter the resistance to aqueous humor outflow, 1 " 3 which suggests that thiols present in the trabecular meshwork (TM) may be involved in modulating aqueous humor outflow resistance. One thiol that may be involved in this process is glutathione (GSH), which has been found to be present in a number of ocular tissues 4 " 6 but whose concentration has not been determined in TM. The present study was designed to determine the level of GSH present in calf TM and to investigate its function. In addition, since the hexose monophosphate shunt (HMPS) is an integral part of GSH metabolism, 7 the presence of this pathway in TM was also investigated. Since our studies to be reported demonstrated the presence of GSH in TM, it was of interest to deplete the level of the tripeptide in TM of perfused calf eyes and study the effect on aqueous outflow facility. For this purpose advantage was taken of diamide that has been shown to be a relatively specific oxidant of GSH 8 and of l,3bis(2-chloroethyl)-l-nitrosourea (BCNU), which is a specific inhibitor of the enzyme glutathione reductase. 9 Of special importance was the possible interaction of GSH in TM with H202, an oxidant that has been found to be a normal constituent of aqueous humor in at least three species including man. " 12 Since aqueous humor is drained via the TM it is conceivable that oxidant stresses that exceed the capacity of TM for detoxification could result in cellular damage and subsequent alteration of aqueous humor outflow resistance. We report here on changes that occur in the facility of aqueous outflow in calf eyes when GSH-depleted TM is exposed to H202. Materials and Methods Calf eyes were obtained from Joseph T. Trelegan and Co. (Cambridge, MA). Shortly after the animals were killed by exsanguination the eyes were enucleated and placed in iced saline solution for transportation and use within 24 hrs. Lenses used in the study were from albino rabbits weighing between 1.8 and 2.2 kg

CRAFT (Cerclage after full dilatation caesarean section): protocol of a mixed methods study investigating the role of previous in-labour caesarean section in preterm birth risk

BACKGROUND: Full dilatation caesarean sections are associated with recurrent early spontaneous preterm birth and late miscarriage. The risk following first stage caesarean sections, are less well defined, but appears to be increased in late-first stage of labour. The mechanism for this increased risk of late miscarriage and early spontaneous preterm birth in these women is unknown and there are uncertainties with regards to clinical management. Current predictive models of preterm birth (based on transvaginal ultrasound and quantitative fetal fibronectin) have not been validated in these women and it is unknown whether the threshold to define a short cervix (≤25 mm) is reliable in predicting the risk of preterm birth. In addition the efficacy of standard treatments or whether benefit may be derived from prophylactic interventions such as a cervical cerclage is unknown. METHODS: There are three distinct components to the CRAFT project (CRAFT-OBS, CRAFT-RCT and CRAFT-IMG). CRAFT-OBS: Observational Study; To evaluate subsequent pregnancy risk of preterm birth in women with a prior caesarean section in established labour. This prospective study of cervical length and quantitative fetal fibronectin data will establish a predictive model of preterm birth. CRAFT-RCT: Randomised controlled trial arm; To assess treatment for short cervix in women at high risk of preterm birth following a fully dilated caesarean section. CRAFT-IMG: Imaging sub-study; To evaluate the use of MRI and transvaginal ultrasound imaging of micro and macrostructural cervical features which may predispose to preterm birth in women with a previous fully dilated caesarean section, such as scar position and niche. DISCUSSION: The CRAFT project will quantify the risk of preterm birth or late miscarriage in women with previous in-labour caesarean section, define the best management and shed light on pathological mechanisms so as to improve the care we offer to women and their babies. TRIAL REGISTRATION: CRAFT was prospectively registered on 25th November 2019 with the ISRCTN registry ( https://doi.org/10.1186/ISRCTN15068651 )

Not All Nitrogen Is Created Equal: Differential Effects of Nitrate and Ammonium Enrichment in Coastal Wetlands

Excess reactive nitrogen (N) flows from agricultural, suburban, and urban systems to coasts, where it causes eutrophication. Coastal wetlands take up some of this N, thereby ameliorating the impacts on nearshore waters. Although the consequences of N on coastal wetlands have been extensively studied, the effect of the specific form of N is not often considered. Both oxidized N forms (nitrate, NO3−) and reduced forms (ammonium, NH4+) can relieve nutrient limitation and increase primary production. However, unlike NH4+, NO3− can also be used as an electron acceptor for microbial respiration. We present results demonstrating that, in salt marshes, microbes use NO3− to support organic matter decomposition and primary production is less stimulated than when enriched with reduced N. Understanding how different forms of N mediate the balance between primary production and decomposition is essential for managing coastal wetlands as N enrichment and sea level rise continue to assail our coasts

DETC2005-84349 HYBRID TARGET TRACKING MANIPULATION THEORIES FOR COMBINED FORCE AND POSITION CONTROL IN OPEN AND CLOSED LOOP MANIPULATORS

ABSTRACT This paper presents a new manipulation theory for controlling compliant motions of a robotic manipulator. In previous closed loop control methods, both direct kinematics and inverse kinematics of a manipulator must be resolved to convert feedback force and position data from Cartesian space to joint space. However, in many cases, the solution of direct kinematics in a parallel manipulator or the solution of inverse kinematics in a serial manipulator is not easily available. In this study, the force and position data are packed into one set of "motion feedback," by replacing the force errors with virtual motion quantities, or one set of "force feedback," by replacing motion errors with virtual force quantities. The joint torques are adjusted based on this combined feed back package. Since only Jacobian of direct kinematics or Jacobian of inverse kinematics is used in the control scheme, the computational complexity is reduced significantly. The applications of this theory are demonstrated in simulation experiments with both serial and parallel manipulators. KEYWORDS Target tracking, open loop, closed loop, manipulation, hybrid control INTRODUCTION In many applications such as deburring, grinding, scribing and contour following, a manipulator is required to follow a predefined position trajectory in the tangent direction of a surface while maintaining a contact force in the normal direction. These tasks need appropriate control of motion and force. In the beginning, a typical force control strategy was used to command an actuator torque. This strategy combined feedback of force with feedback of position (and velocity) and corrected the error through a common controlle

A systematic review of the safety of lisdexamfetamine dimesylate

BACKGROUND: Here we review the safety and tolerability profile of lisdexamfetamine dimesylate (LDX), the first long-acting prodrug stimulant for the treatment of attention-deficit/hyperactivity disorder (ADHD). METHODS: A PubMed search was conducted for English-language articles published up to 16 September 2013 using the following search terms: (lisdexamfetamine OR lisdexamphetamine OR SPD489 OR Vyvanse OR Venvanse OR NRP104 NOT review [publication type]). RESULTS: In short-term, parallel-group, placebo-controlled, phase III trials, treatment-emergent adverse events (TEAEs) in children, adolescents, and adults receiving LDX were typical for those reported for stimulants in general. Decreased appetite was reported by 25-39 % of patients and insomnia by 11-19 %. The most frequently reported TEAEs in long-term studies were similar to those reported in the short-term trials. Most TEAEs were mild or moderate in severity. Literature relating to four specific safety concerns associated with stimulant medications was evaluated in detail in patients receiving LDX. Gains in weight, height, and body mass index were smaller in children and adolescents receiving LDX than in placebo controls or untreated norms. Insomnia was a frequently reported TEAE in patients with ADHD of all ages receiving LDX, although the available data indicated no overall worsening of sleep quality in adults. Post-marketing survey data suggest that the rate of non-medical use of LDX was lower than that for short-acting stimulants and lower than or equivalent to long-acting stimulant formulations. Small mean increases were seen in blood pressure and pulse rate in patients receiving LDX. CONCLUSIONS: The safety and tolerability profile of LDX in individuals with ADHD is similar to that of other stimulants

Extreme Fermi surface smearing in a maximally disordered concentrated solid solution

We show that the Fermi surface can survive the presence of extreme compositional disorder in the equiatomic alloy Ni0.25Fe0.25Co0.25Cr0.25. Our high-resolution Compton scattering experiments reveal a Fermi surface which is smeared across a significant fraction of the Brillouin zone (up to 40% of 2π/a). The extent of this smearing and its variation on and between different sheets of the Fermi surface have been determined, and estimates of the electron mean free path and residual resistivity have been made by connecting this smearing with the coherence length of the quasiparticle states

Thermus and the Pink Discoloration Defect in Cheese

peer-reviewedA DNA sequencing-based strategy was applied to study the microbiology of Continental-type cheeses with a pink discoloration defect. The basis for this phenomenon has remained elusive, despite decades of research. The bacterial composition of cheese containing the defect was compared to that of control cheese using 16S rRNA gene and shotgun metagenomic sequencing as well as quantitative PCR (qPCR). Throughout, it was apparent that Thermus, a carotenoid-producing genus, was present at higher levels in defect-associated cheeses than in control cheeses. Prompted by this finding and data confirming the pink discoloration to be associated with the presence of a carotenoid, a culture-based approach was employed, and Thermus thermophilus was successfully cultured from defect-containing cheeses. The link between Thermus and the pinking phenomenon was then established through the cheese defect equivalent of Koch’s postulates when the defect was recreated by the reintroduction of a T. thermophilus isolate to a test cheese during the manufacturing process. IMPORTANCE Pink discoloration in cheese is a defect affecting many cheeses throughout the world, leading to significant financial loss for the dairy industry. Despite decades of research, the cause of this defect has remained elusive. The advent of high-throughput, next-generation sequencing has revolutionized the field of food microbiology and, with respect to this study, provided a means of testing a possible microbial basis for this defect. In this study, a combined 16S rRNA, whole-genome sequencing, and quantitative PCR approach was taken. This resulted in the identification of Thermus, a carotenoid-producing thermophile, in defect-associated cheeses and the recreation of the problem in cheeses to which Thermus was added. This finding has the potential to lead to new strategies to eliminate this defect, and our method represents an approach that can be employed to investigate the role of microbes in other food defects of unknown origin.Teagasc Walsh Fellowship Programm

Development of a complex intervention to test the effectiveness of peer support in type 2 diabetes

BACKGROUND: Diabetes is a chronic illness which requires the individual to assume responsibility for their own care with the aim of maintaining glucose and blood pressure levels as close to normal as possible. Traditionally self management training for diabetes has been delivered in a didactic setting. In recent times alternatives to the traditional delivery of diabetes care have been investigated, for example, the concept of peer support which emphasises patient rather than professional domination. The aim of this paper is to describe the development of a complex intervention of peer support in type 2 diabetes for a randomised control trial in a primary care setting. METHODS: The Medical Research Council (MRC) framework for the development and evaluation of complex interventions for randomised control trials (RCT) was used as a theoretical guide to designing the intervention. The first three phases (Preclinical Phase, Phase 1, Phase 2) of this framework were examined in depth. The Preclinical Phase included a review of the literature relating to type 2 diabetes and peer support. In Phase 1 the theoretical background and qualitative data from 4 focus groups were combined to define the main components of the intervention. The preliminary intervention was conducted in Phase 2. This was a pilot study conducted in two general practices and amongst 24 patients and 4 peer supporters. Focus groups and semi structured interviews were conducted to collect additional qualitative data to inform the development of the intervention. RESULTS: The four components of the intervention were identified from the Preclinical Phase and Phase 1. They are: 1. Peer supporters; 2. Peer supporter training; 3. Retention and support for peer supporters; 4. Peer support meetings. The preliminary intervention was implemented in the Phase 2. Findings from this phase allowed further modeling of the intervention, to produce the definitive intervention. CONCLUSION: The MRC framework was instrumental in the development of a robust intervention of peer support of type 2 diabetes in primary care. TRIAL REGISTRATION: Current Controlled Trials ISRCTN42541690